Yuxin Wang, PhD, Research Associate, Lerner Research Institute, Cleveland Clinic, Cleveland, USA

Yuxin Wang, PhD is a Research Associate in the Department of Cancer Biology at Lerner Research Institute, Cleveland Clinic. Dr. Wang received his doctoral degree from the joint Ph.D. program at the Lanzhou University in China and Lerner Research Institute Cleveland Clinic in the United States. He performed his postdoctoral training in the laboratory of George Stark at Lerner Research Institute. He has been studying on the crosstalk of cytokine response in cancer cells, and post-translational modification of transcription factors, with a specific focus on STAT2 and IRF9, which are the key factors in type-I-IFN response. His research recently discovered a novel T387 phosphorylation on STAT2, which negative regulates antiviral and anti-proliferative effect of Type-I IFNs. He also disclosed STAT2 collaborated with IRF9 drove a subset of NF-κB genes including IL6. This finding suggested a novel role of the STAT2/IRF9 complex, whose function in cancer cells is not yet well understood.