Sarah Doyle PhD
Assistant Professor in Immunology
Dept. Clinical Medicine, School of Medicine,
JF Coordinator for BSc in Human Health and Disease, TBSI, Head of Immunobiology Research Group, Trinity College Institute of Neuroscience (TCIN), Trinity College Dublin, Dublin, Ireland

Dr. Doyle’s research lab is focused on the impact of signalling downstream of the innate immune Toll/IL-1 Receptor (TIR)-super family in the maintenance of tissue homeostasis and the initiation of pathology. This family recognizes and responds to host derived danger signals and includes the IL-1 family cytokine receptors IL-1R and IL-18R. One aspect of her research is focused on studying how TIR-induced signaling regulates both inherited and acquired retinal degenerative disease, and in particular how IL-18 controls pathological neovascularisation in Age-related Macular Degeneration (AMD)