Lerner Research Inst
Cleveland Clinic Foundation
Dept of Cancer Biology
Dr. Shuvojit Banerjee received his PhD in Biotechnology from the Dr.B.C.Guha Centre for Genetic Engineering and Biotechnology, University of Calcutta (India) in 2008. He then went to the Lerner Research Institute in the Cleveland clinic to perform postdoctoral research in the laboratories of Drs. Charles Foster and Robert Silverman. He was appointed a Research Associate in the Department of Cancer Biology, Lerner Research Institute in 2014.
His current research involves investigation into studies on OAS (2’-5’oligoadenylate synthetase) – RNase L: one of the principal mediators of the innate immune response and thus critically important for human health. In a recent development, he has found that RNase L cleaves self or viral (non-self) RNA to generate small RNA products that can act as activators of host immune response. His project involves the identification of those RNaseL cleaved self or viral RNAs employing new generation RNA sequencing which is essential to host defense against a wide range of viruses and several diseases including cancer. He is also studying how cellular and viral components regulate OAS-RNase L pathway both in viral infection and in tumor microenvironment. Dr. Banerjee has been the recipient of a Milstein Travel Award and a Cleveland Clinic Innovator Award.