Dept. of Biochemistry McGill University Montreal, Canada
Dr. Langlais completed his Ph. D. with honours in Molecular Biology in 2011 under the supervision of Dr. Jacques Drouin at Universite de Montreal, Montreal, Canada and is currently pursuing postdoctoral research in Dr. Philippe Gros laboratory at McGill University. He is now studying the role of the transcription factors IRF8 and IRF1 in the interferon gamma (IFNg) response to infection. Dr. Langlais and colleagues have demonstrated that IRF8 is critical to mount an appropriate inflammatory response, as the mice are susceptible to M. tuberculosis infections but are resistant to neuroinflammation induced by the cerebral malaria model, P. berghei ANKA. Dr. Langlais is now exploring the relative role of IRF8 and its binding partner proteins (IRF1 and PU1) in the macrophage transcriptional response to IFNg. He is also evaluating the role of these transcriptional networks in human tuberculosis and malaria infections, still two of the most deadly diseases world-wide. This work may pave the way toward the identification of novel therapeutic targets against these infections.
Department of Immunology University of Washington Seattle, WA/Gilead Corp.
Dr. Ramos received his Ph.D. in Immunology from UT Southwestern Medical Center in 2009 under the mentorship of Dr. J. David Farrar. More recently, Dr. Ramos’s work has focused on identifying the mechanism by which interleukin-1b (IL-1Î²) and type I interferon cross-talk to promote protective immunity against viral infection. These studies have identified distinct IL-1Î² driven gene signatures that maintain classical interferon-stimulated gene responses to allow for optimal viral control. This work has established a new way of thinking about inflammatory and type I IFN signaling integration that may promote new avenues for the development of therapeutics against disease states in which IL-1Î² and type IFN responses are prevalent. Dr. Ramos is currently a member of the Gilead Sciences Discovery Virology group where he continues his work on cytokine driven viral/host interactions and the development of curative therapeutic interventions against inflammatory and viral diseases in humans.
Department of Microbiology UT Southwestern Medical Center Dallas, TX
Dr. Schoggins received his Ph.D. in 2007 from the Weill Cornell Graduate School of Biomedical Sciences and recently joined the faculty in the Department of Microbiology at UT Southwestern Medical Center. His current efforts are aimed at understanding the mechanisms of action of individual interferon stimulated genes that are otherwise uncharacterized. He is also interested in response of these genes against non-viral pathogens, such as bacteria and fungi, as well as species specific aspects of antiviral immunity. This ongoing work will further solidify our understanding of how the highly pleiotropic interferon system helps orchestrate innate defenses. Taking advantage of these naturally occurring virus inhibitors may be an effective strategy for future development of novel drugs to treat human viral diseases. Dr. Schoggins was elected as the ICIS Secretary for 2018 – 2020.
Young Investigators to Watch for 2018
Here are some of the emerging scientists in the field of interferon and cytokine research:
Dr. Rajsbaum performed his PhD in the laboratory of Anne O’Garra at the MRC-NIMR, London in 2009, and completed his postdoctoral training at Mount Sinai School of Medicine, New York, with Dr Adolfo Garcia-Sastre.