Dr. Reich received her B.A. from Hofstra University and her Ph.D. from the State University of New York at Stony Brook.She performed postdoctoral research in the laboratory of Dr. James Darnell at Rockefeller University where she became interested in the IFN signaling pathways.
In 1988 Dr.Reich became an Assistant Professor in the Department of Pathology, Stony Brook University and became a Full Professor in 2002. In 2004 she moved to the Department of Molecular Genetics and Microbiology at Stony Brook.
Her investigations have led to the discovery of a primary defense response of the cell that is stimulated by dsRNA and is independent of interferon. dsRNA activates a latent transcription factor, designated Interferon Regulatory Factor-3 (IRF-3) th at directly induces a subset of interferon stimulated genes.